It is hard to argue with the fact that speculation has been one of the most, if not the most, significant factors in the Wuhan virus pandemic.
There has been speculation as to the origins of the virus. Was it man made? Did it originate in a Wuhan lab or did it arise de novo from a Chinese wet market in the city? Despite over six months of more attention than any microbe has received in recorded history, there is still legitimate speculation about its origins.
Speculation has been especially prevalent in the modeling of the course of the virus and its lethality. Early models predicted 2.2 million deaths in the US and over 500 thousand in the United Kingdom, without mitigation, e.g. social distancing, wearing masks, etc. Experts now agree those numbers were wildly overestimated. We are now well over six months into this pandemic and the US only recently exceeded 200 thousand deaths and the UK is barely at 42 thousand. We mitigated. Now what?